Search results for "Drug side effects"

showing 7 items of 7 documents

A two-gene epigenetic signature for the prediction of response to neoadjuvant chemotherapy in triple-negative breast cancer patients

2019

Background Pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) in triple-negative breast cancer (TNBC) varies between 30 and 40% approximately. To provide further insight into the prediction of pCR, we evaluated the role of an epigenetic methylation-based signature. Methods Epigenetic assessment of DNA extracted from biopsy archived samples previous to NAC from TNBC patients was performed. Patients included were categorized according to previous response to NAC in responder (pCR or residual cancer burden, RCB = 0) or non-responder (non-pCR or RCB > 0) patients. A methyloma study was performed in a discovery cohort by the Infinium HumanMethylation450 BeadChip (450K arra…

0301 basic medicineOncologymedicine.medical_treatmentADNlcsh:MedicineTriple Negative Breast NeoplasmsEpigenesis Genetic0302 clinical medicineGenetics (clinical)Triple-negative breast cancermedicine.diagnostic_testHigh-Throughput Nucleotide SequencingNuclear ProteinsMethylationMiddle AgedNeoadjuvant TherapyGene Expression Regulation NeoplasticTreatment OutcomeMyogenic Regulatory FactorsEfectes secundaris dels medicaments030220 oncology & carcinogenesisCohortFemaleTaxoidsMetilacióMicrotubule-Associated ProteinsAdultmedicine.medical_specialtylcsh:QH426-470MethylationMinor Histocompatibility Antigens03 medical and health sciencesBreast cancerTriple-negative breast cancerInternal medicineCell Line TumorBiopsyGeneticsmedicineHumansEpigeneticsMolecular BiologyEpigenetic signatureAgedChemotherapybusiness.industryGene Expression ProfilingResearchlcsh:RSequence Analysis DNADNADNA Methylationmedicine.diseaseHuman geneticsRepressor Proteinslcsh:Genetics030104 developmental biologyDrug side effectsbusinessPredictionDevelopmental Biology
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Drug‐refractory myasthenia gravis: Clinical characteristics, treatments, and outcome

2022

[Objective] To describe the clinical characteristics and outcomes in patients with refractory myasthenia gravis (MG) and to determine the effectiveness and side effects of the drugs used for their treatment.

Maleprogressive multifocal leukoencepdiarrheacholinergic receptorplasma exchangemiddle agedadultimmunologic factornauseaanemiahypertrichosisageddrug withdrawaldiabetes mellitusdisease severityTRIALsafetycorticosteroidhypertensionImmunologyMiastenia gravismethotrexateArticlebulbar paralysispancytopeniaMuscular DiseasescompulsionMyasthenia Gravischolinesterase inhibitorcross-sectional studyHumansImmunologic FactorshumanRITUXIMABarthralgiaNeurologíaMalalties muscularsAgedRetrospective Studiesmyasthenia gravisleukopeniaabdominal painDrug testingmajor clinical studyCross-Sectional StudiesDrug side effectscyclophosphamideobservational studyNeurology (clinical)immunoglobulinFEATURESefficacyclinical outcomeelectrophysiological procedurescomputer assisted tomographyDOUBLE-BLINDTratamiento médicorituximabOutcome Assessment Health CareImmunologiamuscle specific tyrosine kinaseRegistriestacrolimusazathioprineMedicamentoGeneral Neurosciencenephrotoxicitygeneral condition deteriorationhyperplasiatrialMiddle Agedliver toxicitydrug toxicityunclassified drugfemaleEfectes secundaris dels medicamentsSAFETYFemaledouble-blindheadacheblindnessAdultAssaigs clínics de medicamentsmalefeaturesfollow uppneumoniacyclosporinemycophenolate mofetilprotein tyrosine kinaseimmunosuppressive agentallergyalopeciaEFFICACYclinical featureosteopeniaSpainprednisonehyperglycemiaautoantibodyFollow-Up Studies
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Pelvic exenterations for primary rectal cancer: analysis from a 10-year national prospective database

2018

Aim: to identify short-term and oncologic outcomes of pelvic exenterations (PE) for locally advanced primary rectal cancer (LAPRC) in patients included in a national prospective database. Methods: few studies report on PE in patients with LAPRC. For this study, we included PE for LAPRC performed between 2006 and 2017, as available, from the Rectal Cancer Registry of the Spanish Association of Surgeons [Asociación Española de Cirujanos (AEC)]. Primary endpoints included procedure-associated complications, 5-year local recurrence (LR), disease-free survival (DFS) and overall survival (OS). A propensity-matched comparison with patients who underwent non-exenterative surgery for low rectal canc…

MaleColorectal cancerEpidemiologymedicine.medical_treatment030230 surgerycomputer.software_genre0302 clinical medicinePostoperative ComplicationsRetrospective StudieMedicineProspective StudiesOutcomeDatabaseGastroenterologyGeneral MedicineMiddle AgedColorectal surgeryTreatment OutcomeEfectes secundaris dels medicaments030220 oncology & carcinogenesisFemaleHumanAdvanced rectal cancermedicine.medical_specialtyRisk AssessmentDisease-Free SurvivalPelvis03 medical and health sciencesColorectal surgeryCàncer colorectalAdvanced rectal cancer Colorectal surgery Complication Outcome Pelvic exenterationRetrospective Cohort StudyHumansPerioperative PeriodEpidemiologiaAgedNeoplasm StagingRetrospective StudiesRectal NeoplasmPelvic exenterationbusiness.industryRectal NeoplasmsRectummedicine.diseaseColorectal cancerPelvic Exenterationbody regionsProspective StudieQuality of LifeDrug side effectsPostoperative ComplicationPelvic exenterationNeoplasm Recurrence LocalbusinessComplicationComplicationcomputer
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Medication-related osteonecrosis of the jaw associated with implant and regenerative treatments : systematic review

2019

Background The aim of this study was to determine if the treatment with bisphosphonates other anti-resorptive and antiangiogenic agents influences the success of regenerative and / or implant treatments. Material and Methods We reviewed the literature from the last 5 years in the PubMed database, using the following words: “Sinus Floor Augmentation”[Mesh] OR “Dental Implants”[Mesh]) OR “Guided Tissue Regeneration”[Mesh]) AND “Osteonecrosis”[Mesh]. The articles were selected following the inclusion and exclusion criteria and were evaluated using the 22 items of the STROBE declaration. The following PICO clinical question was applied: Does the treatment with agents associated with drug osteon…

Dental Restoration FailureSinus Floor AugmentationBone RegenerationDatabases FactualMEDLINESinus Floor AugmentationDentistryReviewRessenyes sistemàtiques (Investigació mèdica)law.invention03 medical and health sciences0302 clinical medicineRandomized controlled triallawSystematic reviews (Medical research)medicineOssosAnimalsHumansDental Restoration FailureMethodological qualityGeneral DentistryDental ImplantsBonesDiphosphonatesImplants dentalsbusiness.industryDental Implantation EndosseousDental implantsOsteonecrosisAntibodies Monoclonal030206 dentistryMedically compromised patients in Dentistrymedicine.disease:CIENCIAS MÉDICAS [UNESCO]OtorhinolaryngologyEfectes secundaris dels medicamentsInclusion and exclusion criteriaUNESCO::CIENCIAS MÉDICASDrug side effectsSurgeryImplantbusinessOsteonecrosis of the jawDrug Antagonism
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Modeling Drug-Induced Anorexia by Molecular Topology

2012

Molecular topology (MT) has demonstrated to be a very good technique for describing molecular structures and to predict physical, chemical, and biological properties of compounds. In this paper, a topological-mathematical model based on MT has been developed for identifying drug compounds showing anorexia as a side effect. An external validation (test set) has been carried out, yielding over an 80% correct classification in the active and inactive compounds. These results reinforce the role of MT as a potential useful tool for predicting drug side effects.

DrugSide effectChemistryGeneral Chemical Engineeringmedia_common.quotation_subjectExternal validationGeneral ChemistryAnorexiaLibrary and Information SciencesModels BiologicalAnorexiaComputer Science ApplicationsDrug DesignTest setBiological propertymedicineHumansDrug side effectsMolecular topologymedicine.symptomBiological systemmedia_commonJournal of Chemical Information and Modeling
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Effectiveness of substituting cyclosporin A with tacrolimus in reducing gingival overgrowth in renal transplant patients

2009

Objectives: this study aims to evaluate the effectiveness of periodontal therapy combined with tacrolimus in the suppression of gingival overgrowth (GO) and the effect on GO of changing from cyclosporin A to tacrolimus. Patients and methods: sixteen renal transplant patients, averaging 52 years of age, whose kidney function was stable and were receiving treatment with cyclosporin A, were randomly assigned to one of two groups. In the experimental group, patients were instructed in oral hygiene and underwent periodontal treatment, whereas in the control group, only oral hygiene instructions were given. After the first visit and the change of medication from cyclosporine to tacrolimus in both…

ImmunosupressióMalalties de les genivesTrasplantament renalTherapeutic useImmunosupressive agentsMalalties periodontalsTherapeuticsTerapèuticaCiclosperinaGum diseasesKidney transplantationsurgical procedures operativeEfectes secundaris dels medicamentsÚs terapèuticCyclosporineDrug side effectsImmunosupressorsPeriodontal diseaseUNESCO:CIENCIAS MÉDICASImmunosuppression
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Adverse side effects of statins in the oral cavity

2008

Podeu consultar la versió en castellà a http://hdl.handle.net/2445/117363

Mouth diseasesEfectes secundaris dels medicamentsSymptomsUNESCO::CIENCIAS MÉDICASDrug side effectslipids (amino acids peptides and proteins)HipercolesterolèmiaHypercholesteremiaMalalties de la boca:CIENCIAS MÉDICAS [UNESCO]Símptomes
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